abstract：:In an open study the acceptability of a newly designed vaginal ring was evaluated. The ring, being developed for contraceptive purposes, was made of Silastic and did not contain any medication. Three groups of 10 healthy female volunteers were selected after informed consent. The 6 nulliparous and 24 parous women were...

journal_title：Contraception

authors： Roumen F,Dieben T,Assendorp R,Bouckaert P

更新日期：1990-08-01 00:00:00

abstract：:The present study was designed to evaluate the effectiveness of a once-weekly regimen of GnRH antagonist followed by a progestin as a potential new contraceptive method. On menstrual cycle days 2, 9, 16, and 23 (onset of menses = Day 1) monkeys were divided into two groups: 1) those injected sc with 0.1 mg/kg Nal-Glu ...

journal_title：Contraception

authors： Danforth DR,Williams RF,Hsiu JG,Roh SI,Hahn D,McGuire JL,Hodgen GD

更新日期：1990-06-01 00:00:00

abstract：:High speed cinematography of latex condoms inflated to burst under standard (ISO) conditions reveals that rupture of the condom typically is initiated at a small focal point on the shank of the condom and then rapidly propagates throughout the condom's surface, often ending with partial or full severance of the condom...

journal_title：Contraception

authors： Stube R,Voeller B,Davidhazy A

更新日期：1990-06-01 00:00:00

abstract：:A pharmaceutical and pharmacokinetic study was carried out on levonorgestrel tablets from two different sources (Hungarian- and Chinese-made). Both preparations contained 0.75 mg levonorgestrel and had been shown to have similar contraceptive efficacy and side effects when used for postcoital contraception. Absorption...

journal_title：Contraception

authors： He CH,Shi YE,Liao DL,Zhu YH,Xu JQ,Matlin SA,Vince PM,Fotherby K,Van Look PF

更新日期：1990-05-01 00:00:00

abstract：:A large international multi-center IUD data set (N = 5520) coordinated by Family Health International was analysed to determine if the uterine position of a woman (anteverted, mid-positioned or retroverted) affects the ease of IUD insertion and if knowledge of uterine position would diminish insertion-related problems...

journal_title：Contraception

authors： Chi IC,Farr G,Dominik R,Robinson N

更新日期：1990-05-01 00:00:00

abstract：:Intrauterine devices releasing 20 micrograms/day levonorgestrel were inserted in 10 women (ages 25-34). Bleeding and spotting patterns were recorded on a menstrual card during one year of follow-up. Blood samples were collected for radioimmunoassays of LH, estradiol (E2), progesterone (P) and levonorgestrel (LNG) and ...

journal_title：Contraception

authors： Xiao BL,Zhou LY,Zhang XL,Jia MC,Luukkainen T,Allonen H

更新日期：1990-04-01 00:00:00

abstract：:Comparative phase I clinical trials were carried out in 5 centres with three formulations of beta-hCG-based vaccines inducing antibodies against human chorionic gonadotropin. The objectives of these trials were to determine their relative immunogenicity, duration, reversibility and safety. A total of 116 tubal ligated...

journal_title：Contraception

authors： Talwar GP,Hingorani V,Kumar S,Roy S,Banerjee A,Shahani SM,Krishna U,Dhall K,Sawhney H,Sharma NC

更新日期：1990-03-01 00:00:00

abstract：:An injectable method of obtaining vas deferens occlusion is presented. The agent used is styrene maleic anhydride (SMA) with dimethyl sulphoxide as the solvent. The special feature of the approach is that after a period of time, spermatozoa passage is spontaneously reestablished. By varying the dose of SMA administere...

journal_title：Contraception

authors： Guha SK,Anand S,Ansari S,Farooq A,Sharma DN

更新日期：1990-03-01 00:00:00

abstract：:Eighty-four Chinese patients attending the Family Planning Association of Hong Kong for contraception with oral contraceptive pills were randomized into 2 groups. The first group received pills containing 0.15 mg levonorgestrel and 0.03 mg ethinyl oestradiol. The second group received pills containing 0.15 mg desogest...

journal_title：Contraception

authors： Ho PC,Liu WT,Kwan MS

更新日期：1990-01-01 00:00:00

abstract：:The effects of two triphasic oral contraceptives containing the same amount of ethinylestradiol (EE) in combination with levonorgestrel (LNG) or gestodene (GES), respectively, on lipid metabolism and coagulation were studied. Serum concentrations of GES and LNG were determined at the same time. Thirty-three healthy wo...

journal_title：Contraception

authors： Kjaer A,Lebech AM,Borggaard B,Refn H,Pedersen LR,Schierup L,Bremmelgaard A

更新日期：1989-12-01 00:00:00

abstract：:This study examines contraceptive delivery characteristics and their association with contraceptive behavior. Data were collected in telephone interviews from a national sample of 1057 women who were using female contraceptives. The overwhelming majority of the sample obtained contraceptive services from gynecologists...

journal_title：Contraception

authors： Harvey SM,Beckman LJ,Murray J

更新日期：1989-12-01 00:00:00

abstract：:A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study the pharmacokinetics of a single dose of 50 mg RU 486 administered orally to 12 women on day 7 of the cycle. The dose was rapidly absorbed with peak plasma concentration between 1 and 2 hours. Distribution was also rapid (me...

journal_title：Contraception

authors： He CH,Shi YE,Ye ZH,Zhang GG,Jiang NX,Van Look PF,Fotherby K

更新日期：1989-10-01 00:00:00

abstract：:This study was undertaken to assess the effects of different tubal occlusion procedures on ovarian function. Three groups of subjects randomized to tubal occlusion by laparoscopy and Yoon ring (24 subjects), minilaparotomy and Yoon ring (19 subjects) and minilaparotomy and Pomeroy (22 subjects), and one separate contr...

journal_title：Contraception

authors： Rivera R,Gaitan JR,Ruiz R,Hurley DP,Arenas M,Flores C,Hernandez AB

更新日期：1989-08-01 00:00:00

abstract：:Mechanisms for the therapeutic effect of oral contraceptives in dysmenorrhea were studied by recording intrauterine pressure on the first day of menstrual bleeding in women with moderate to severe symptoms and after three weeks of oral contraceptive therapy (150 micrograms levonorgestrel + 30 micrograms ethinyl estrad...

journal_title：Contraception

authors： Ekström P,Juchnicka E,Laudanski T,Akerlund M

更新日期：1989-07-01 00:00:00

abstract：:There is agreement that the relative risk of developing pelvic inflammatory disease (PID) increases among women who use the intrauterine contraceptive device (IUD). The role of Chlamydia in causing PID among IUD users is not clear. The present study demonstrates that Chlamydia trachomatis growth can be inhibited in cu...

journal_title：Contraception

authors： Kleinman D,Sarov I,Insler V

更新日期：1989-06-01 00:00:00

abstract：:Saponins isolated from Sapindus mukorossi have potent spermicidal activity. Morphological changes in human ejaculated spermatozoa after exposure to these saponins were evaluated under Scanning Electron Microscope. The minimum effective concentration (0.05% in spot test) did not affect the surface topography after expo...

journal_title：Contraception

authors： Dhar JD,Bajpai VK,Setty BS,Kamboj VP

更新日期：1989-05-01 00:00:00

abstract：:The results of a prospective longitudinal controlled study comparing the coagulation effects of a standard low-dose combined oral contraceptive (Microgynon 30), a desogestrel-containing pill (Marvelon) and a triphasic preparation (Triquilar) after one year's treatment in ethnic Chinese women is presented in this paper...

journal_title：Contraception

authors： Prasad RN,Koh S,Ratnam SS

更新日期：1989-04-01 00:00:00

abstract：:Fructose levels and fructolysis index in human semen were analysed to assess a correlation, if any, between the levels of this glycolysable sugar and sperm concentration. Semen was collected from normospermic men and men with azoospermia or oligospermia. Seminal fructose levels were elevated in men with obstructive az...

journal_title：Contraception

authors： Rajalakshmi M,Sharma RS,David GF,Kapur MM

更新日期：1989-03-01 00:00:00

abstract：:A study was conducted to evaluate the effect of NORPLANT use on hemoglobin levels (HB), packed cell volume (PCV) and menstrual bleeding patterns. NORPLANT insertions were performed on 50 healthy volunteers in Ilorin, Nigeria, between January-March 1986. Whole blood samples were collected at admission, 6-month and 12-m...

journal_title：Contraception

authors： Fakeye O,Balogh S

更新日期：1989-03-01 00:00:00

abstract：:This study was undertaken with a view to investigate the possible mechanism(s) of antifertility action of gossypol acetate in rats and hamsters. Adult male rats were treated by gavage with 30 mg/kg/day of gossypol for 7 weeks and adult male hamsters were treated similarly with 20 mg/kg/day gossypol for 8 weeks. The tr...

journal_title：Contraception

authors： Srivastava A,Gupta G,Setty BS

更新日期：1989-03-01 00:00:00

abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the ...

journal_title：Contraception

authors： Singh K,Viegas OA,Koh S,Singh P,Ratnam SS

更新日期：1989-02-01 00:00:00

abstract：:Injection of a polymer, styrene maleic anhydride (SMA), into the lumen of the vas deferens of rats, was observed to have effective and reversible contraception. The safety evaluation of the polymer, for 90 days, was carried out in Charles Foster male rats. There have been no significant changes in any of the toxicity ...

journal_title：Contraception

authors： Sethi N,Srivastava RK,Singh RK

更新日期：1989-02-01 00:00:00

abstract：:The advantages of delivering drugs through the skin for systemic therapy have been widely recognized and represent a growing sector in drug development. Transdermal delivery of steroids is also a rapidly expanding field and in various clinical situations where hormonal replacement therapy is needed this route of admin...

journal_title：Contraception

authors： Sitruk-Ware R

更新日期：1989-01-01 00:00:00

abstract：:A simple survey was made of health-care providers to determine their attitudes toward oral contraceptives containing more than 50 mcg of estrogen. It was found that about two-thirds of respondents prescribe this group of medication, although few do so regularly. Their use seemed correlated with providers 40 years of a...

journal_title：Contraception

authors： Grossman RA

更新日期：1988-11-01 00:00:00

abstract：:In this longitudinal study involving 100 Singaporean acceptors, the effects of Norplant-2 rods on metabolic function was evaluated. With respect to liver function, the results indicate possible hepatocellular dysfunction. There was a significant rise in mean serum bilirubin from 0.54 mg/dl to 0.85 mg/dl after 12 month...

journal_title：Contraception

authors： Singh K,Viegas OA,Liew D,Singh P,Ratnam SS

更新日期：1988-10-01 00:00:00

abstract：:Mifepristone (RU 486; Roussel-Uclaf, Paris, France) is an antiprogesterone used for termination of very early pregnancy. The ripening effect of Mifepristone on the human pregnant cervix was studied in 42 healthy women from 7 to 11 weeks gestation. The women were randomly allocated to oral treatment of either 100 mg Mi...

journal_title：Contraception

authors： Rådestad A,Christensen NJ,Strömberg L

更新日期：1988-09-01 00:00:00

abstract：:A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using the levonorgestrel subdermal implants NORPLANT for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicate that these subjects may have an increased predisposition to thrombosis as e...

journal_title：Contraception

authors： Viegas OA,Singh K,Koh S,Singh P,Ratnam SS

更新日期：1988-09-01 00:00:00

abstract：:Increased menstrual blood loss (MBL) associated with intrauterine device (IUD) use may precipitate or aggravate iron deficiency anaemia, adversely affecting the health of women particularly those from developing countries. Studies were conducted to define the association of MBL and iron status in South American women;...

journal_title：Contraception

authors： Andrade AT,Pizarro E,Shaw ST Jr,Souza JP,Belsey EM,Rowe PJ

更新日期：1988-07-01 00:00:00

abstract：:Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm m...

journal_title：Contraception

authors： Majumdar SS,Sharma RK,Das RP

更新日期：1988-06-01 00:00:00

abstract：:In a prospective double-blind study of the effects of two low-dose oral contraceptives (OCs) on lipid and lipoprotein metabolism, two groups of eighteen young healthy women selected at random were submitted to a six months' use of either monophasic ethinylestradiol (EE) + desogestrel (DG) or triphasic EE + levonorgest...

journal_title：Contraception

authors： Harvengt C,Desager JP,Gaspard U,Lepot M

更新日期：1988-06-01 00:00:00

abstract：:The purpose of this study was to investigate the efficacy and the acceptability of Prazosin as a male contraceptive pill. Acceptable antifertility drugs for men are proving difficult to produce, and the possibility of using pharmacological agents to block selectively or to inhibit normal sperm transport through the ma...

journal_title：Contraception

authors： Kjaergaard N,Kjaergaard B,Lauritsen JG

更新日期：1988-06-01 00:00:00

abstract：:This communication is to report the effects of gossypol on the synthesis of chromosomal basic proteins in the spermiogenic cells. A double-labelling experiment has been performed. The control rats received 14C-arginine, whereas the gossypol-treated rats received a 3H-arginine injection. An equal volume of the tissues ...

journal_title：Contraception

authors： Teng CS,Fei RR

更新日期：1988-03-01 00:00:00

abstract：:The overall and renal toxicity of racemic gossypol acetic acid was assessed in 6 mongrel dogs. Oral racemic gossypol acetic acid was given orally at doses increasing from 10 to 40 mg/d for a total of 6 weeks in 3 female dogs and from 40 to 80 mg/d for a total of 4 weeks in 3 male dogs. The animals were then sacrificed...

journal_title：Contraception

authors： van Ypersele de Strihou C,Dieu JP,Marbaix E

更新日期：1988-02-01 00:00:00

abstract：:Mature rabbits received norethisterone-3-oxime (NETO) 2 mg/kg/day from day 2 through day 4 of pregnancy by gavage. Control rabbits were given vehicle. All animals were sacrificed on day 5. The oviducts were removed and sections stained with HE. Morphological changes were evaluated. The outer and inner diameters of tub...

journal_title：Contraception

authors： Li QG,Li DZ

更新日期：1987-12-01 00:00:00

abstract：:The effect of DL-204, 2-(3-ethoxyphenyl)-5,6-dihydro-5-triazole (5,1a)-isoquinoline, a non-hormonal post-implantational anti-fertility drug, on tissue weights, nucleic acids and total protein concentrations in the testes, ventral prostate and seminal vesicles were evaluated in immature and sexually mature rats, while ...

journal_title：Contraception

authors： Prasad RS,Vijayan E

更新日期：1987-11-01 00:00:00

abstract：:The effect of eight common local mineral water drinks in Ile-Ife, Nigeria (seven cola and one lemon-based) on sperm motility in vitro was carried out. There was no significant difference in the pH values of all the drinks, the pH ranged between 2.30-2.50. After one minute, Pepsi-Cola had the least inhibitory effect on...

journal_title：Contraception

authors： Oyelola OO,Ayangade SO,Amole F

更新日期：1987-10-01 00:00:00

abstract：:The mechanism of action of intrauterine devices varies from one type of device to another, although the principle of action is the same, namely, to interfere with the physiology of reproduction at the endometrial level. The biochemical changes of the endometrial tissue and the composition of the uterine fluid have bee...

journal_title：Contraception

authors： Johannisson E

更新日期：1987-07-01 00:00:00

abstract：:This report describes the long-term follow-up of 376 women who received NORPLANT implants in the period October 1974 through May 1979. One-hundred-and-ten subjects received replacement implants after variable lengths of use of the first set. The average levonorgestrel plasma levels declined steadily through eight year...

journal_title：Contraception

authors： Díaz S,Pavez M,Miranda P,Johansson ED,Croxatto HB

更新日期：1987-06-01 00:00:00

abstract：:The metabolic effects of a new oral contraceptive Femodene (SHD 356C) containing 75 micrograms gestodene (delta-15-levonorgestrel) and 30 micrograms ethinyloestradiol were studied in two groups of women. Group 1 consisted of women not currently using oral contraceptives; Group 2 consisted of women switching to Femoden...

journal_title：Contraception

authors： Fotherby K,Trayner I,Longthorne PN,Lee B,Watson HR

更新日期：1987-04-01 00:00:00

abstract：:The antiprogestin ZK 98.299 (11 beta-(4-dimethylaminophenyl)-17 alpha-hydroxy-17 beta-(3-hydroxypropyl)-13 alpha-methyl-4,9-gonadien-3-one) was administered s.c. (30mg/day) to two groups of cycling bonnet monkeys. In Group I (n = 6), it was injected from day 16 to 18 and in Group II (n = 9) from day 21 to 23 of the cy...

journal_title：Contraception

authors： Puri CP,Elger WG,Pongubala JM

更新日期：1987-04-01 00:00:00